Holland require a win against the Czech Republic to qualify for Euro 2016, but it has been a disastrous night for Danny Blind’s side so far.
Pavel Kaderabek opened the scoring with this effort, while Josef Sural doubled the lead for the visitors shortly after.
As a result, the hosts trail 0-2 at half time in Amsterdam and with Turkey currently holding a two-point lead over them in the race for third spot in Group A to secure a playoff berth, the Dutch are on the brink of missing out on Euro 2016 next summer.
Iceland and Czech Republic have both already secured their place in the tournament, but with 45 minutes to save their qualifying campaign, it remains to be seen whether or not the Dutch can turn things around and claim third place instead of Turkey.
Former Manchester United star Robin van Persie entered the fray late on in the first half, as the Netherlands look to add to their 15 goals in this campaign, which is worryingly short of their tally in qualifying for Euro 2012 where they scored 37 goals.
They were given hope after Marek Suchy was sent off for bringing Memphis Depay down when seemingly clear through on goal, and so they will look to make the most of their man advantage after the break.