Man United kick their Champions League campaign off on Tuesday night when they travel to Holland to face PSV in their opening group game.
Louis van Gaal’s Red Devils navigated their way past Club Brugge in the playoff round to reach this stage, but they will start the next chapter without Wayne Rooney.
The 29-year-old missed the 3-1 win over Liverpool on Saturday due to a hamstring injury, and it has been confirmed that he will be absent again on Tuesday.
As a result, Marouane Fellaini is expected to continue up front, although Anthony Martial will certainly have given Van Gaal something to think about with his instant impact after coming off the bench to score against their bitter rivals.
Nevertheless, the Belgian ace is likely to get the nod with his 19-year-old teammate set to come off the bench again if needed.
Meanwhile, this will be a special game for Memphis Depay who faces his old club after his summer move to Old Trafford.
The Dutch winger has struggled so far this season, but he will be hoping that a return to familiar surroundings will bring out the best in him after catching the eye of numerous European giants with his form in his homeland last season.
United will have several individuals with plenty of experience of playing against Dutch opposition, particularly with Van Gaal and Daley Blind who know all about the atmosphere that they should expect at the Philips Stadion when they face Phillip Cocu’s men.
However, having strengthened the core of their squad over the summer and with David de Gea returning to the starting line-up, they will be confident of returning to Manchester with a positive result.