Check out some of the amazing highlights the pair have produced over the years.
They will both go down in history as two of the best to have ever played the game, and as you would expect, they have produced thrilling tennis together.
Rafael Nadal will face Novak Djokovic for the 37th time in their careers and the third time they have faced each other in the final of the US Open.
The number one seeded Serb is playing in his fourth consecutive final in New York and has played in five all up in his glittering career.
Perhaps crucially in Djokovic’s favor is that he has won twice as many matches against Nadal when they face on hard courts, with the Serb winning 10-5.
Overall Nadal has the edge in their career match-up having won 21 of their 36 previous matches with the latest incarnation set to be another classic.