The clash between these two sides has thrown up some great results down the years.
In the most highly anticipated match of the Premier League weekend Chelsea host Manchester United in a fixture that has been highly entertaining down the years.
Since the new league format was established in 1992, here are the best games between the Blues and the Red Devils.
Chelsea 1-0 Manchester United, Premier League, 2004
When Jose Mourinho arrived as manager at Stamford Bridge in 2004 the Portuguese coach was a whirlwind of opinions, arrogance and charm.
The boss also showed he had talent when beating United early on in the 04/05 season, before going onto win the title that year.