The hapless Spanish striker could make way for the English hitman…
Up top, Jermain Defoe should start ahead of Roberto Soldado, who had another fruitless afternoon last weekend against Manchester City.
Christian Eriksen and Danny Rose are still out injured, meaning Jan Vertonghen will continue to deputise at left-back, while Mousa Dembele or Paulinho could be given a more advanced attacking midfield spot.
In defence, Michael Dawson should partner Vlad Chiriches in the centre, if the Romanian is fit enough to start the game, while Kyle Walker will play at right back.
Andre Villas-Boas earned criticism for his high defensive line against Man City, and may elect to play a more cautious formation against Manchester United, with his traditional 4-3-3 adaptable to a 4-2-3-1 if necessary.
On the wings, Andros Townsend and Gylfi Sigurdsson have been first choice for much of the season, but Aaron Lennon’s return to fitness gives AVB a selection dilemma.