DC: Eric Dier
Promising youngster Eric Dier has largely been a regular starter for Spurs this season and should get the nod from Pochettino once again here.
DC: Jan Vertonghen
A top class centre-back on his day, Jan Vertonghen seems likely to start against Southampton and will be an important performer if Spurs are to take the points.
MC: Nabil Bentaleb
A terrific young midfielder, Nabil Bentaleb has improved this season and can put in another strong midfield display here.
MC: Ryan Mason
Another emerging youngster at White Hart Lane, Ryan Mason should get another start as he continues to impress for the club.