Read a preview of the Rugby Championship clash and watch a live stream of the action.
Where: Estadio Malvinas Argentinas, Mendoz
When: 21.00 (BST)
Watch live: Click here to watch on NowTV from Sky!
South Africa will be looking to extend their seven game unbeaten run and make it eight wins in a row when they face Argentina in the second round of the Rugby Championship.
The Springboks have not achieved this feat since 2007 to 2008 when they won 13 consecutive matches.
The last time South Africa failed to win was in October last year when they lost 32-16 to New Zealand in the inaugural Rugby Championship.
Argentina have won three of their last five matches and will be aiming to beat South Africa for the first time on Saturday.
Argentina’s most recent losses came against England in June when they lost 51-26
Morne Steyn makes his 40th Test start at flyhalf, extending his record as the most capped starting flyhalf for South Africa after he made his Test debut in a 26-21 win against the British and Irish Lions in 2009.
Ruan Pienaar wins his 67th cap for South Africa and his 20th start at scrum half after he made his debut as a replacement in a 45-26 loss to New Zealand in 2006.
While the cap milestones continues as Juan Martin Hernandez wins his 40th Test cap for
Argentina on Saturday.
South Africa has never lost to Argentina in the 15 Tests they have played against them, with the closest the Pumas have come to the upset being a lone draw.
The Springboks ran rampant last weekend in the first round of The Rugby Championship as they belted the Argentina side 73-13.