Both teams face their season slipping away from them if they lose in week four.
Where: Edward Jones Dome
When: 01.25 (BST)
Watch live: Click here to watch on NowTV from Sky!
The San Francisco 49ers will be out to keep their Superbowl dreams alive when they travel to take on the St Louis Rams at the Edward Jones Dome in week four of the NFL season.
Entering the round with a surprising 1-2 record, the 49ers, a team many pundits expected to go close if not win the NFC this season, face a Rams side in a similar predicament.
San Francisco were on the end of a humbling 27-7 loss at the hands of the Colts last round and star quarterback Colin Kaepernick came in for much of the criticism.
The backlash by NFL and 49ers fans on social media was severe and swift, however, Kaepernick took to trolling his followers on Twitter by favoriting their abusive tweets.
However, the fans had a point after the San Francisco playcaller only managed to throw for 150 yards on 13-27 attempts for no touchdowns and another picked pass.
Worryingly for head coach Jim Harbaugh his side has only generated 44 points in its first three games.
However, if they are to change that the 49ers might look to exploit a Rams front seven that leaked yards against the running game of the Dallas Cowboys last weekend.
Cowboys running back scored the rams for 175 yards on 26 carries, and it is numbers like that will have 49ers RB Frank Gore licking his lips.
San Francisco was criticised for not using Gore enough last round in their loss to the Colts as he looked dangerous on his way to 82 yards on 11 carries.
“After the show we put on Sunday, I’d run the ball too,” Rams end Chris Long said.
“We have to fix those things. If you have a subpar performance, there’s nothing you can ask more than to have a great running team like San Francisco to see where we’re at. They’re going to come in and try to run the football, they always do, that’s how they’re built and it’s up to us to be up to the task.”
Gore had long been a thorn in the Rams’ side, but they have slowed him down over the teams’ four meetings the past two seasons.
Last year, the Rams limited Gore to 3.5 yards per carry on his 44 attempts.
However, in further bad signs for the 49ers, Vernon Davis and Patrick Willis remain in severe doubt to take on the Rams.