Favre has played in the NFL since December 2010.
The St. Louis Rams reportedly tried to tempt Brett Favre out of retirement following the news that quarterback Sam Bradford suffered a season ending injury.
The 44-year-old played his last game in the league for the Minnesota Vikings back in December 2010, and has since become a grandfather while enjoying the family life.
However, he has left the Rams disappointed after insisting that he is neither in mental of physical condition to return to NFL action.
“It’s flattering, but you know there’s no way I’m going to that,” he said according to ESPN.
“I had a great career. I think if anything, the last year that I played was an obvious writing-on-the-wall vision for you, if you will,” he said. “It was time.”
The Rams have instead signed veteran quarterback Brady Quinn who was released by the New York Jets earlier this week, while also recalling Austin Davis.
Davis spent 2012 and the 2013 pre-season with the Rams, but will act as a back-up for Kellen Clemens who will get his first start of the season when St. Louis host the Seattle Seahawks on Monday night.
The move to bring in Quinn has also dismissed early speculation that the Rams could look at bringing in Tim Tebow, as they frantically looked to fill the roster in Bradford’s absence.
The first choice quarterback suffered a knee injury which has now ruled him out for the remainder of the season, and it remains to be seen how his team fare without him during his spell on the sidelines.
St. Louis are currently sat in third place in the NFC West behind the Seahawks and the San Francisco 49ers, and will be hoping to improve on their 3-4 record so far this season.