Where: Estadio Municipal José Zorrilla
When: Saturday 17 August, 20:00 BST
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Both clubs go into the new season under new management, so it promises to be an intriguing clash at the Estadio Municipal Jose Zorrilla.
Real Valladolid replaced Miroslav Djukic with Juan Ignacio Martinez this summer and the new manager has wasted no time in making his mark in the transfer market, with eight new faces already at the club and more signings expected before the end of the month.
Zakarya Bergdich and Gilberto Garcia are both expected to make their deubt in the home clash against Athletic Bilbao, but Victor Perez and Daniel Larsson will both miss out through injury.
Athletic, meanwhile, replaced the controversial but talented Marcelo Bielsa with Ernesto Valverde and new recruits Benat Extebarria and Kike Sola are expected to start for the Basque visitors.
Mikel Balenziaga could well play against the side he spent last season on loan with.