RWB – Antonio Valencia
With Rafael having only just returned we expect the Ecuador international to maintain his place at right wing-back.
LWB – Daley Blind
Another new signing now with the Dutchman being acquired from Ajax for £13.8m and Blind is an extremely versatile option.
CM – Darren Fletcher
Although he has his critics, with Michael Carrick and Marouane Fellaini out the Scot could well be needed as a defensive option.
CM – Ander Herrera
The debuts keep on coming as after signing from Athletic Bilbao for £29m this Spaniard then suffered an injury, but is back and ready to play now.
CAM – Angel di Maria
Became the British record transfer upon completing his £59.7m move from Real Madrid and impressed last time out against Burnley and is expected to replace Juan Mata.