Will the under-fire Moyes give Zaha his first Champions League minutes?
David Moyes is definitely without Marouane Fellaini, Shinji Kagawa, Michael Carrick and Chris Smalling, while Nemanja Vidic and Patrice Evra are both doubtful.
With United already qualified though, Moyes will have no problem testing out some of his lesser tried players, with Wilfried Zaha in particular in line for a rare start.
Dutch left-back Alex Buttner will likely get a start too, as will Brazilian midfielder Anderson, who is likely to play alongside Phil Jones.
Up top, English duo Danny Welbeck and Wayne Rooney could well lead the line.