Despite injury concerns the home side is ready to face the best in the world.
England will be out to show why they are ranked the third best rugby union side in the world when they tackle a gruelling schedule of Autumn internationals this year.
After showing promising signs last domestic season, with a thumping 38-21 victory over New Zealand in December coupled with a close loss to Wales for the Six Nations crown, head coach Stuart Lancaster will know good things are just around the corner.
However, the English leader will have his fair share of headaches ahead of the first game against Australia on November 2 with several big names either out injured or racing against time to be passed fit.
Centre Manu Tuilagi suffered a torn pectoral muscle in Leicester’s game against Newcastle in the Aviva Premiership and will need six weeks recovery and possible surgery.
Flanker Tom Croft has been ruled out for the rest of the season after suffering knee ligament damage in what was a blow, as the British and Irish Lions loose forward would have been one of the first chosen in the English side.
Croft has been working his way back to full-fitness after a potentially career-ending neck injury, but he will be forced to be a spectator ahead of the upcoming internationals against the Southern Hemisphere teams.
Adding to the English depth issues at centre, Brad Barritt has been ruled out of action until at the earliest Christmas or possibly 2014, after undergoing surgery on ligaments in his foot.
Barritt, 27, had been one of the mainstays of the English backline since Lancaster took over the side three years ago and had been a dependable option in attack and always sturdy defender.
Despite the injury woes, Lancaster still has plenty of class remaining in his elite squad. The remaining core will have to be careful not to add themselves to the ever growing list.
So training tough, and Maximuscle shop products will take centre stage in the battle to stay fit for the upcoming visit of the Southern Hemisphere power houses.
Up front and Dylan Harley, Alex Corbisiero and Mako Vunipola will spend plenty of time working on scrummaging at training ahead of locking horns with the fearsome packs of New Zealand and Argentina.
Captain Chris Robshaw, who will been keen to show why the British Lions should have picked him for the recent Australian tour, and Ben Youngs need to link both the forwards and backs together.
While classy fly-half Owen Farrell will need to use all of his guile and ability to read the play as he looks to steer the young but exciting English backline around the park.
New Zealand will pose the toughest upcoming challenge having looked dominant in all of their Rugby Championship games this season befitting their status as world champions.
Australia are slowly starting to come together under new coach Ewan McKenzie but could be exposed by the hosts at set-piece time along with at the ruck.
While Argentina will have nothing to lose in playing the English, however, again the home side should have too much class and should come away with an easy victory.