Wozniacki has endured a downward spiral at the Aussie Open since reaching the semi’s in 2011.
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Azarenka missed the bulk of 2014 through injury, but had no trouble in disposing Wozniacki 6-4, 6-2.
The eighth-seeded Dane reached the semi-finals of the Australian Open in 2011, but has since struggled to make a similar impact on the first major of the season.
“I think it’s a curse I’ve gotten here. I’ve made semis, then quarters (2012), then fourth round (2013), then third round (2014), this year second round,” Wozniacki is quoted as saying by Reuters.
“It’s kind of gone that way the last few years. Hopefully I’m going to break that next year and start going the other way.
“I love this tournament and I’m so sad to be out already. Obviously it was a tough draw for both of us. But, you know, she came out on top and played better.”
Azarenka faces 26th Barbora Zahlavova Strycova in the next round.