Sagna may have to deputise at centre-half at the Stadium of Light.
Arsenal are facing a defensive crisis ahead of their crucial Premier League visit to Sunderland on Saturday.
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Club captain Thomas Vermaelen has joined left-back Kieran Gibbs on the sidelines, while Laurent Koscielny is facing a late fitness test.
If the Frenchman does not make it, boss Arsene Wenger may be forced to use full-back Bacary Sagna as an auxiliary centre-half alongside Per Mertersacker, with Carl Jenkinson slotting in at right-back.
Koscielny was substituted in the second half of France’s 2-1 friendly defeat to Germany on Wednesday with a suspect calf strain.
Deadline day signing Nacho Monreal is fit to make his second start at left-back, ahead of unfancied Brazilian Andre Santos.
With Tottenham facing Newcastle in the early kick-off at White Hart Lane, the Gunners could start the match seven points behind their North London rivals in the race for fourth place.
In his pre-match press conference, Wenger seemed relaxed about his defensive problems but admitted the Black Cats pose a significant attacking threat.
“They have real offensive potential, with Johnson, Fletcher, Sessegnon and now Danny Graham,” the Frenchman told reporters.
Wenger stressed that the race for a place in next season’s Champions League was far from over and says there will be more twists in the final third of the season.
“It is possible there will be another twist, and that is what I believe. We still have to make up ground,” he added.