Sunderland star could also feature according to various reports.
Southampton striker Pablo Osvaldo is expected to lead the Italy attack as they go in search of all three points in Denmark on Friday night.
The Azzurri have already qualified for the World Cup, but Cesare Prandelli will want his side to continue their impressive form with victory also ensuring that they will be a top seed in the draw in December.
With Mario Balotelli injured, Osvaldo will likely step in and take his place with Antonio Candreva and Alessandro Diamanti acting as his support in an attacking trident.
However, there are various reports suggesting that Emanuele Giaccherini could start in place of one of those mentioned above, with Giuseppe Rossi also returning to the international fold after overcoming his injury woes.
It is understood that Prandelli has been testing out various systems with differing personnel in training ahead of Friday’s clash, with Thiago Motta, Riccardo Montolivo and Claudio Marchisio possibly making up the midfield trio.
Andrea Pirlo is likely to be rested, while PSG starlet Marco Verratti has fitness concerns and is a doubt to feature.
Meanwhile, Daniel Agger, Christian Eriksen and Nicklas Bendtner are amongst the Premier League contingent that will likely feature for the home side, as they look to pick up a morale boosting victory as the qualifying round draws to a close.
Nevertheless, it is unlikely to be an easy feat despite their impressive performance when these two sides met in Italy in the reverse fixture, but Prandelli will be eager to maintain the belief and confidence within the Azzurri camp.
Probable Italy Line-up: Buffon; Balzaretti, Chiellini, Ranocchia, De Silvestri; Thiago Motta, Montolivo, Marchisio; Diamanti, Candreva, Osvaldo.