Several sides left scrambling after just two rounds of the season.
The Canberra Raiders were the hardest hit by injury after the second round of the NRL season, with key backrower Josh Papalii set to miss at least six weeks.
Papalli suffered ankle syndesmosis on Sunday after his ankle buckled underneath him when tackled from behind against the Newcastle Knights at Hunter Stadium.
Chris Lawrence has again suffered a leg injury, with the Wests Tigers star set to miss some time due to a hamstring strain picked up in round two.
Gold Coast Titans forward Greg Bird is expected to have only suffered a pinched nerve on the weekend, but the club are awaiting on results from scans to show the extent of any possible damage.
BRONCOS
Justin Hodges (Achilles, round six)
David Stagg (knee, round four)
Jordan Kahu (knee, round four)
Corey Oates (knee, indefinite)
BULLDOGS
Tim Lafai (broken hand, round three)
Damien Cook (broken hand, round five)
Drury Low (broken hand, round four)
Sam Kasiano (foot, TBC)
Krisnan Inu (jaw, round six)
COWBOYS
Lachlan Coote (ACL, season)
Hezron Murgha (knee, mid-season)
DRAGONS
Jack De Belin (leg, TBC)
Michael Witt (dislocated shoulder, round three)
Josh Dugan (knee, round five)
EELS
Jacob Loko (knee, indefinite)
Lee Mossop (shoulder, mid-season)
KNIGHTS
Darius Boyd (hamstring, round four)
Jarrod Mullen (hamstring, round 10)
Zane Tetevano (broken hand, round three)
Clint Newton (bicep, season)
PANTHERS
Tim Grant (ribs, round three)
Dave Simmons (knee-cap, TBC)
James Roberts (broken ankle, round seven)
Eto Nabuli (knee, round four)
Wes Naiqama (pectoral, indefinite)
George Jennings (dislocated elbow, mid-season)
Luke Capewell (turf toe, round seven)
Sika Manu (shoulder, round four)
Bryce Cartwright (wrist, round three)
RABBITOHS
Luke Keary (pectoral, mid-season)
RAIDERS
Josh Papalii (ankle, round six)
David Shillington (ribs, round three)
ROOSTERS
Isaac Liu (knee, indefinite)
SEA EAGLES
Brett Stewart (hamstring, round five)
Jorge Taufua (shoulder, round three)
Tom Symonds (back, indefinite)
SHARKS
Paul Gallen (ankle, round six)
Todd Carney (hamstring, round two)
Luke Lewis (shoulder, round five)
Beau Ryan (neck, round three)
Anthony Tupou (knee, mid-season)
Jeff Robson (facial fractures, indefinite)
STORM
Matt Duffie (ACL, season)
Justin O’Neill (knee, indefinite)
TIGERS
Chris Lawrence (hamstring, TBC)
Curtis Sironen (foot, mid-season)
Liam Fulton (concussion, round three)
Tim Simona (shoulder, round three)
Dene Halatau (ankle, mid-season)
Tim Moltzen (knee, indefinite)
TITANS
Greg Bird (shoulder, TBC)
Beau Falloon (medial ligament tear, TBC)
Ryan James (shoulder, round three)
Matt Srama (shoulder, round four)
WARRIORS
Thomas Leuluai (groin, round three)
Kevin Locke (knee, indefinite)
COMMENTS