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Where: Excel Centre, London
When: 18.00 (GMT)
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Victory over the Italy-based Cuban for the fringe IBF inter-continental lightweight title will move Mitchell closer to a crack at Mexican Miguel Vazquez for the world title.
Mitchell, 29, is ranked eighth in the world.
And the East Ender knows he can not afford any more setbacks after being stopped in four rounds by Scotsman Ricky Burns for the WBO version of the world title last year.
Mitchell said: “Zamora is ranked number seven in the world.
“And if I can’t get guys like him out the way, what else can I do?
“If I win this it will put me higher up the rankings and closer to the IBF champion Vasquez.”
Zamora, though, insists Mitchell is not a genuine lightweight and has been unimpressed with the Londoner’s two wins this year.
He said: “Kevin Mitchell is still a super-featherweight.
“In my opinion, he made a mistake moving up from super-feather.”