Plenty of changes for both sides ahead of their Autumn international.
Where: Stadio Olimpico, Rome
When: 14.00 (GMT)
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Italy coach Jacques Brunel will hand former Scotland under-20 player Tommaso Allan his full debut when the Azzurri host Argentina in the third and final test of their November series on Saturday.
Italy-born Allan, who has made substitute appearances for Italy after being drafted into the squad last month, is one of three changes for the clash against the Pumas at the Olympic Stadium.
The 20-year-old Perpignan replaces Luciano Orquera, who drops to the bench, with Michele Campagnaro starting at outside centre in place of veteran Gonzalo Canale.
Canale moves to inside centre to replace Luca Morisi, who has been sidelined since last week having suffered a heavy tackle early in a 37-31 win over Fiji which required him to have his spleen removed.
Robert Barbieri comes back into Brunel’s starting XV at openside flanker, replacing Mauro Bergamasco who is not included in the matchday squad.
Both No. 8 and captain Sergio Parisse and prop Martin Castrogiovanni will start, meaning the pair will pick up their 101st caps for Italy to pull level with retired scrum-half Alessandro Troncon.
Retired prop Andrea Lo Cicero holds the record for Italy’s most caps on 103.
Argentina coach Daniel Hourcade has made five changes to the side that suffered a 40-6 thumping by Wales last week ahead of the Pumas’ test against Italy in Rome on Saturday,
Argentina’s defeat at the Millennium Stadium was their second in succession after defeat to England but with Italy in less than spectacular form the Pumas can scent a possible first win of the series.
Among the forwards, Worcester’s Mariano Galarza replaces Patricio Albacete in the second row while Benjamin Macome comes in at No. 8 for Pablo Matera, who drops to the bench.
Hourcade has made three changes among the backs with right wing Lucas Amorosino replacing Horacio Agulla, who has moved from right wing to outside centre where he replaces Marcelo Bosch.
Gabriel Ascarate of Glasgow Warriors replaces Santiago Fernandez at inside centre and on the left wing Racing-Metro’s Juan Imhoff replaces Santiago Cordero, who drops to the bench.
Saturday’s match will be the 19th meeting between the sides, with Argentina winning 12 of the previous 18 encounters.
Joaquin Tuculet; Lucas Amorosino, Horacio Agulla, Gabriel Ascarate, Juan Imhoff; Nicolas Sanchez, Martin Landajo; Benjamin Macome, Julio Farias-Cabello, Juan Manuel Leguizamon (capt); Mariano Galarza, Manuel Carizza; Maximiliano Bustos, Eusebio Guinazu, Marcos Ayerza
Replacements: Santiago Iglesias Valdez, Nahuel Lobo, Matias Diaz, Tomas Lavanini, Pablo Matera, Tomas Cubelli, Javier Rojas, Santiago Cordero
Luke McLean; Giovambattista Venditti, Michele Campagnaro, Gonzalo Canale, Tommaso Iannone; Tommaso Allan, Edoardo Gori; Sergio Parisse (capt), Robert Barbieri, Alessandro Zanni; Valerio Bernabo, Quintin Geldenhuys; Martin Castrogiovanni, Leonardo Ghiraldini, Michele Rizzo
Replacements: Davide Giazzon, Matias Aguero, Lorenzo Cittadini, Marco Bortolami, Joshua Furno, Tobias Botes, Luciano Orquera, Tommaso Benvenuti.