Read a preview of the game and watch all of the action live.
Where: Candlestick Park
When: 21.25 (BST)
Watch live: Click here to watch on NowTV from Sky!
In what is a mouth-watering way for the season to start for both teams, the Green Bay Packers will face off against the San Francisco 49ers at Candlestick Park.
In what is a re-match of the NFC divisional round clash last season, all eyes will be on the quarterbacks in this one.
Aaron Rogers, the superstar of the Packers and arguably the best player in the league, will be out for a measure of retribution.
While in the other corner stands Colin Kaepernick who lead his side to a stunning 45-1 victory over the Packers the last time the teams met.
For Green Bay it was their second straight divisional loss after lifting the Super Bowl trophy in 2011,
After losing in the Super Bowl last year and the NFC Championship game the year before, the next logical step for San Francisco is to be crowned champions at Metlife Stadium. Jim Harbaugh will hope their 2013 season begins in the same matter as last year – a win against Green Bay (30-22 at Lambeau Field).