Get all of the latest information and then watch all of the action live.
Where: Scostoun Stadium,
When: 20.00 (GMT)
Watch live: Click here to watch on NowTV from Sky!
Glasgow headed to Cardiff last week knowing that victory in the Welsh capital would have seen them sitting pretty at the halfway stage of the campaign and with two home games still to come.
Defeat at the Arms Park has left them with at the foot of the table, though, and they now face an uphill struggle to reach the last eight given that Toulon won at Exeter on the same weekend.
Gregor Townsend’s men failed to even pick up a losing bonus point in Round 3, meaning a maximum point haul on home soil is now even more important to their hopes of a maiden Heineken Cup quarter-final.
The Scottish side have only once played knockout rugby in Europe and that was in the form of a quarter-final play off which ended in a 90-point drubbing by Leicester Tigers back in 1997.
If the Warriors are looking for omens hinting at a reverse in fortunes in Round 4, then a 47-32 success at Hughenden in 2001 would fit that bill seeing as it came just a week after they’d been thrashed 46-7 in Cardiff.
But history pointed in their favour prior to last Friday’s fixture as well, with Glasgow having secured five straight wins over the Blues since February 2011.
As for the Welsh outfit, Phil Davies’ troops are on a major Heineken Cup high after receiving rave reviews for their performance last time out.
Victory over holders Toulon in Round 2 was a huge result for the region but they still weren’t expected to back it up given that they sit ninth in the RaboDirect PRO12, some 13 points behind third-placed Glasgow thanks to just three league wins all season.
But back it up they did, and in some style, too. The Blues bounced back from a 31-6 mauling by Munster in their previous outing at the Arms Park despite missing a host of big names through injury, including British & Irish Lions skipper Sam Warburton.
Warburton won’t be fit to feature on Friday, either, as he is awaiting specialist advice on a ‘stinger’ problem with his shoulder.
Lions wing Alex Cuthbert marked his return from ankle damage with a well-taken try last week but the Blues’ injury crisis has since deepened with the news that centre Dafydd Hewitt won’t be available for selection.
Hewitt becomes the fourth midfielder to be ruled out, with Owen Williams, Cory Allen and Gavin Evans already out of action.
Hewitt’s absence leaves Davies with only one fit centre in Richard Smith and takes the number of unavailable players up to 13.