Fulham lost at home to a rampant first half performance from Manchester United, with Antonio Valencia, Robin Van Persie and Wayne Rooney scoring at Craven Cottage.
Manchester United overcame Fulham and Manchester City smashed seven goals past Norwich City in the Premier League on Saturday, but Chelsea were dealt a shock defeat at Newcastle United.
A day that also witnessed a freak goal by Stoke City goalkeeper Asmir Begovic was set to conclude with a table-topping affair between leaders Arsenal and closest rivals Liverpool.
Despite a disappointing start to the season, United have now gone six games without defeat in all competitions following a 3-1 win over Fulham at Craven Cottage.
David Moyes’s side went 3-0 up inside 22 minutes, with Antonio Valencia tapping in a ninth-minute opener from Wayne Rooney’s square pass.
Robin van Persie’s emphatic finish from Adnan Januzaj’s measured through ball made it 2-0 and the Dutchman then centred for Rooney to add a third.
Alex Kacaniklic pulled a goal back for Fulham in the 65th minute with a shot that deflected in off Rooney, but the champions saw out a victory that elevated them to within two points of the top four.