Read a full preview and watch streaming from Tuesday’s Group A encounter in Fortaleza.
Where: Estadio Castelao, Fortaleza
When: 20:00 BST
Watch live: Click here to watch on BBC Sport online!
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Hosts Brazil go into their clash with Mexico knowing that three points would be likely to secure the Selecao’s safe passage through to the secound round of the 2014 FIFA World Cup.
Despite a not entirely convincing performance in victory against Croatia on opening night, manager Luiz Felipe Scolari will be confident of leading his side into the latter stages of the tournament.
Mexico, however, are also in the position of having won their opening game, which should make for a fascinating contest in Fortaleza as both sides look to secure their passage into the last sixteen.
Brazil have one injury doubt from the 11 that took to the field against Niko Kovac’s side, with forward Hulk struggling with an injury that he suffered in training just two days before the match.
This could clear the way for Willian or Bernard to make their first stars of the tournament, with the diminutive attacking midfield duo both having featured as substitutes against Croatia and being the natural replacements for the Zenit St. Petersburg man.
Mexico manager Miguel Herrera looks to have a fully fit squad to select from, meaning that Manchester United star Javier Hernandez is likely to once again miss out after struggling to impress as a substitute in their narrow 1-0 victory over Cameroon.
This means that former Tottenham Hotspur and Barcelona attacking midfielder Giovani Dos Santos is likely to start just off Oribe Peralta, the player who scored the winning goal against the Indomitable Lions and remains Mexico’s chief goal threat.